The neurobiology of a gut feeling.

A gut-brain neural circuit for nutrient sensory transduction.
Kaelberer MM, Buchanan KL, Klein ME, Barth BB, Montoya MM, Shen X, Bohórquez DV.
Science. 2018 Sep 21;361(6408). pii: eaat5236. doi: 10.1126/science.aat5236.

In 1853, Sydney Whiting wrote in his classic Memoirs of a Stomach, “…and between myself and that individual Mr. Brain, there was established a double set of electrical wires, by which means I could, with the greatest ease and rapidity, tell him all the occurrences of the day as they arrived, and he also could impart to me his own feelings and impressions.” 165 years later the underlying neural circuits and transmitters mediating gut-brain sensory transduction still remain unknown. Here, we documented a fast mechanism for the brain to feel the food sensed by the gut.